Hi, I'm Johannes
A scientist and open-source enthusiast situated in Boston, MA. Currently, I work as a research specialist in the Grigorieff Lab at UMass Chan Medical School/HHMI.
My research interests are the mechanism of mechanosensation during hearing and hematopoietic differentiation and malignancies. I love developing new methods to understand how these things work. At the moment, I believe that cryo-electron microscopy of native tissues is the best path to solve my research questions.
I enjoy creating software and visualizations using Python, whatever web-technology is hot right now, Blender, and C++.
If you want to talk about science, software, or anything in between you can contact me by email or Slack: jojotux123 at hotmail.com.
Papers
Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen
Serrano A, Puerner C, Plumb E, Chevalier L, Elferich J, Sinn LR, Grigorieff N, Ralser M, Delarue M, Bassilana M, Arkowitz RA
bioRxiv 2024 Nov 17
bioRxiv
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
Matsui A, Spangler C, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu , Gouaux E
eLife 2024 Nov 4
PubmedbioRxiv
CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples
Elferich J, Kong L, Zottig X, Grigorieff N
bioRxiv 2024 Feb 28
bioRxivCodeCode
Single molecule studies of the native hair cell mechanosensory transduction complex
Clark S, Mitra J, Elferich J, Goehring A, Ge J, Ha T, Gouaux E
bioRxiv 2023 Dec 12
bioRxivTalks
Workflows for In-Situ Structural Biology Using DeCo-LACE and cisTEM
New England Cryo-EM meeting 2023 (Yale) 2023
SlidesCodeCryo-EM imaging of biomolecular complexes in their native environment: From the rare mechanosensory transduction complex to the abundant ribosome
Seminar at OHSU 2022
SlidesCodeImaging molecules in their native environment: Cryo-electron tomography of PCDH15 complexes in mouse stereocilia
Gatan webinar 2022
RecordingSlidesCodeHigh-throughput in-situ cryo-EM of hematopoietic differentiation
SBGrid Consortium talk 2021
RecordingStructures
Software
Scientific web visualizations
DeCo-LACE viewer
An OpenSeadragon and Blender based visualization of DeCo-LACE montaged 2DTM data.
WebsiteCode
